Need an Ergonomic Mouse? 7 Great Options to Choose From

Tired of those wrist aches and finger cramps after a long workday or a particularly intense gaming session? Then you need an ergonomic mouse. Designed to alleviate discomfort and prevent issues like carpal tunnel, trigger finger, and muscle strain, an ergonomic mouse can truly make a world of difference by putting your hand in a natural, relaxed position. Stick around as we dive into seven outstanding options that’ll bring you the relief you want.

Tip: pair your new mouse with an ergonomic mechanical keyboard to relieve even more discomfort.

1. Best Wireless Ergonomic Mouse: Logitech MX Master 3S

Price: ‎$99.99

Our favorite wireless ergonomic mouse, and arguably the most universally recommendable ergonomic mouse on this list, is the Logitech MX Master 3S. While not as aggressively ergonomic as some competitors, the MX Master 3S is still supremely comfortable, thanks to its hand-sculpted shape that supports your palm and fingers with textured surfaces for a confident grip.

Logitech Mx Master 3s Side View

But comfort isn’t the only thing the MX Master 3S excels in; its tech specs are equally impressive. Sporting an 8,000 DPI optical sensor, this mouse offers unparalleled precision – even on glass surfaces. The dual scroll wheels, designed for horizontal and vertical scrolling, support Logitech’s MagSpeed Electromagnetic technology, allowing you to scroll 1,000 lines per second, so reading long documents and web pages is a breeze.

On a single charge, the MX Master 3S can last up to 70 days, thanks to its efficient battery management. When you need to charge it, you’ll find that a mere three minutes of quick charging can power the device for a full day’s work, making battery life one less thing to worry about. Connect the ergonomic mouse to your device using Bluetooth or the included USB receiver to use it with anything from a desktop computer to various mobile devices.

Logitech Mx Master 3s Ergonomic Mouse


  • Versatile ergonomic design
  • High-precision 8,000 DPI optical sensor
  • Two scroll wheels
  • Can pair with up to three devices
  • Fast charging


  • Not ideal for smaller hands
  • No storage compartment for the USB receiver

Also helpful: wireless ergonomic mice need regular charging, and the best charging stations can help ensure that you always have a free charging port available.

2. Best Vertical Ergonomic Mouse: Logitech Lift

Price: $66.99

Unlike your traditional mouse, the Logitech Lift places your hand vertically oriented, making it the best ergonomic mouse for carpal tunnel syndrome, a condition caused by excessive pressure on the median nerve at the wrist. The relatively compact size of the mouse makes it ideal for people with small or medium-sized hands. (Those with larger hands should go with the Logitech MX vertical ergonomic mouse instead.)

Vertical Ergonomic Mouse Logitech Lift 1

If you enjoy color-matching your computer accessories, you’ll be pleased to know that the Lift comes in three different colors: pink, white, and black. But this ergonomic mouse can offer much more than stylish looks. It can run for up to two years on a single AA battery, so you can focus less on keeping an eye on the battery level indicator and more on getting things done.

The Lift offers dual connection options via Bluetooth or the included USB receiver, which can be stored neatly inside the mouse itself. Press the Easy-Switch button to switch between up to three connected devices, and you’re ready.

Woman Using Logitech Ergonomic Mouse for Carpel Tunnel


  • Optimal vertical angle for wrist comfort
  • SmartWheel technology for adaptive scrolling
  • Long-lasting two-year battery life on a single AA battery
  • Comes in three stylish colors


  • Not suitable for larger hands
  • Limited number of programmable buttons

3. Best Wired Ergonomic Mouse: Nulea Wired Vertical Mouse

Price: $19.99

The Nulea Wired Vertical Mouse combines the assurance of a stable, lag-free wired connection with an ergonomic design. With this mouse, you’re not going to lose connection at a crucial moment, and you don’t have to worry about charging batteries. For some folks, especially gamers or professionals who require precision and uninterrupted usability, being wired is far from a drawback – it’s a feature.

Man Using Wired Ergonomic Mouse Nulea Mouse

You also don’t have to worry about discomfort, as the Nulea Wired Vertical Mouse sits at a 57-degree angle, which puts your hand and wrist into a more natural posture. Long-term comfort is also increased by the included dedicated forward/backward buttons and non-slip scroll wheel.

While the RGB lights illuminating the outline of the mouse won’t be everyone’s cup of tea, all users – regardless of their aesthetic preferences – can easily appreciate the option to switch between four DPI levels. By choosing the optimal DPI level for the task at hand, you can, for example, enjoy smoother browsing, more accurate editing, or quicker response times in gaming.

Nulea Mouse on a Desk


  • Reliable wired connection ensures zero lag
  • Four adjustable DPI levels
  • Affordably priced
  • Great build quality, considering the price


  • Forward/backward buttons are not macOS-compatible
  • Base could be wider to prevent unintentional tilting

Good to know: connect multiple monitors to your MacBook Air with a few simple steps.

4. Best Ambidextrous Ergonomic Mouse: Razer Viper 8K

Price: $39.98

If you’re left-handed, your options for a truly ergonomic mouse are painfully limited. That’s where ambidextrous designs like the Razer Viper 8K come into play, offering the best comfort you can get. The main thing that makes this relatively normal-looking mouse so comfortable is its lightweight design. At just 71 grams, the Viper 8K allows easy maneuverability without causing wrist strain.

Viper 8k Ergonomic Gaming Mouse

Of course, it wouldn’t be a Razer gaming mouse if it didn’t pack a punch in the performance department. The Viper 8K is equipped with Razer’s proprietary Focus+ 20K Optical Sensor, which delivers pinpoint accuracy and zero spinouts. Coupled with an impressive 8000Hz HyperPolling rate, this mouse communicates its position to your computer at lightning speed, reducing input latency to almost zero.

But the real cherry on top is the Viper 8K’s Speedflex Cable. Designed for minimal drag and greater flexibility, the cable allows for quicker, smoother swipes. The mouse also features advanced onboard memory, which lets you store up to five profiles. This is especially handy for those who frequently switch between different setups for work and play.

Ergonomic Mouse Viper 8k 1


  • Lightweight ambidextrous design
  • High-performance optical sensor
  • Speedflex Cable minimizes drag
  • Can store multiple profiles


  • Traditional design can’t match the comfort provided by vertical mice

5. Best Trackball Ergonomic Mouse: MX Ergo Advanced Wireless Trackball

Price: $79.00

The Logitech MX Ergo Advanced Wireless Trackball is an excellent choice for those who would like to eliminate those small, repeated wrist movements that often cause strain and discomfort. It includes a trackball that you control with your thumb, letting you navigate with precision, while your hand remains in a fixed, ergonomic position.

Trackball Ergonomic Mouse Mx Ergo 1

The angle of the MX Ergo mouse can be adjusted between 0° and 20°. This customization can make a difference when you’re putting in those long hours at the computer. Couple that with the trackball’s advanced precision-mode tracking, and you’re looking at a guaranteed solution to most common and not-so-common wrist issues.

With its dual connectivity, you can link up to two different devices to the MX Ergo, and toggle between them effortlessly. The built-in battery can be charged using any standard USB-C cable, which should last up to four hours on a charge.

Measurements of Mx Ergo Mouse


  • Can eliminate wrist movements
  • Angle adjustment for personalized comfort
  • Long-lasting rechargeable battery
  • Multiple programmable buttons


  • Trackball design may take some time to get used to

Good to know: there are many reasons to get a trackball mouse. We break them down for you.

6. Best Ergonomic Gaming Mouse: Razer DeathAdder V3

Price: $69.99

Weighing in at just 59 grams, the Razer DeathAdder V3 is so lightweight that you’ll barely feel it in your hand. Less weight means less drag, less fatigue, and more comfort during those long gaming sessions. So even though this mouse doesn’t have the most ergonomic design in the world, it does a lot to keep your wrist pain-free.

Deathadder Ergonomic Gaming Mouse

The Razer DeathAdder V3 is an ergonomic gaming mouse equipped with the Focus Pro 30K optical sensor, which offers flawless tracking performance on all common surfaces, and it communicates its position and clicks to your PC up to 8000 times a second via the Speedflex cable.

Also worth mentioning are the Gen-3 optical mouse switches, engineered for an impressive 90-million-click lifecycle, boasting a blazing fast 0.2ms actuation with zero debounce delay. This means your clicks register almost instantaneously.

Ergonomic Gaming Mouse Deathadder In Dark


  • Ultra-lightweight design for increased comfort
  • Exceptional sensor performance
  • Extremely low input latency
  • Durable, responsive optical switches


  • Wired connectivity may bother some

Tip: Some games are more comfortable to play with a gamepad. Fortunately, you can choose from many gamepads for PC.

7. Best Budget Ergonomic Mouse: Microsoft Bluetooth Ergonomic Wireless Mouse

Price: $34.99

When it comes to ergonomics on a budget, the Microsoft Bluetooth Ergonomic Wireless Mouse has you covered. This affordable ergonomic mouse is slightly tilted to promote a more natural hand position, reducing wrist strain during marathon work or gaming sessions. It also features a soft thumb rest for extended, comfy use.

Microsoft Bluetooth Ergonomic Wireless Mouse Color Options

The Microsoft Bluetooth Ergonomic Wireless Mouse has a Teflon base that’s equipped with a precise tracking sensor so that it glides and registers easily on just about any surface. And with three customizable buttons, you can add app-specific functions that boost your productivity levels.

If you like your electronic devices to be both functional and aesthetically pleasing, then the Microsoft Bluetooth Ergonomic Wireless Mouse can offer four color options (blue, peach, black, and white). While we consider the use of AAA batteries to be a downside, some may see it as a positive, as they can be instantly replaced.

Woman Using Microsoft Bluetooth Ergonomic Mouse


  • Comes in four colors
  • Comfortable ergonomic design for extended use
  • Smooth gliding, thanks to the Teflon base
  • Multi-device pairing


  • No DPI presets
  • Uses disposable AAA batteries

Frequently Asked Questions

How do ergonomic mice differ from traditional mice in terms of design?

Ergonomic mice often feature unique shapes, angles, and grips that aim to minimize discomfort during extended use. Some common types include vertical mice that hold your hand in a “handshake” position, and trackball mice that allow you to navigate without moving your arm or wrist.

How much time does it take to get used to a vertical ergonomic mouse?

The time it takes to get used to a vertical ergonomic mouse can vary from person to person, but generally speaking, most users take between a few days to a few weeks to adjust.

Can ergonomic mice be used effectively for gaming, or are they mainly for office use?

Yes, ergonomic mice can be used effectively for both gaming and office tasks.

Image credit: Canva

David Morelo
David Morelo

David Morelo is a professional content writer in the technology niche, covering everything from consumer products to emerging technologies and their cross-industry application. His interest in technology started at an early age and has only grown stronger over the years.

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